ROLE OF METABOLIC DYSFUNCTION IN ADVANCED PROSTATE CANCER
RESEARCHER PROFILE
Dr Jennifer Gunter (Filmed March 2024)
Senior Research Associate (Cancer Metabolism),
Australia Prostate Cancer Research Centre – Queensland (APCRC-Q) & Group Leader, Cancer Metabolism Group,
Translational Research Institute (TRI),
Queensland, Australia
Dr Jennifer (Jenni) Gunter is a mid-career researcher, with a metabolic research background spanning almost 15 years. She leads a research team examining the metabolic plasticity of cancer cells with the aim of identifying therapeutic targeting strategies that extend patient survival. Jenni completed her PhD in 2005 at the Oxford Centre for Diabetes, Endocrinology and Metabolism at Oxford University.
She returned to Australia in 2006 with a University of Queensland Postdoctoral Fellowship at the UQ Diamantina Institute to pursue studies into the turnover and metabolism of adipocytes in obesity.
In 2010, Jenni joined the Institute of Health and Biomedical Innovation, at QUT to research the intersection between chronic metabolic disorders and their emerging relationship to cancer. These studies were focused on the role of insulin and the relationship between the insulin and androgen signalling axes.
Dr Gunter was drawn to the area of prostate cancer research and the intersection between chronic metabolic disorders and their emerging relationship to cancer. Her strengths include expertise in the metabolic syndrome, insulin signalling and metabolism, and she has a demonstrated record of successful and productive research projects in metabolic research where she now applies her efforts to understanding the role of metabolic dysfunction in advanced prostate cancer.
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Metabolic phenotyping, lipidomics & bioinformatics in dementia
Dr Luke Whiley is a dementia researcher whose work focuses on understanding how the body’s metabolism, particularly the biology of fats known as lipids, influences our health throughout ageing.
His research explores how the body responds to illness, lifestyle, and environmental stress at a chemical level, and how these responses shape longterm disease risk. Using advanced blood-based measurement technologies, Dr Whiley studies thousands of small molecules at once to build a snapshot of a person’s metabolic health. By combining these measurements with data science approaches, his work identifies biological pathways that become disrupted in disease, providing insight into why some people are more vulnerable to conditions such as dementia.
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CASE STUDY Link between levels of extracellular vesicles in the blood and tissue damage caused by diseases
A landmark study led by WEHI and La Trobe University has found a potential new diagnostic marker that could be used to better detect the level of tissue damage in our bodies.
This study revealed, for the first time, a link between levels of EVs in the blood and tissue damage caused by diseases such as leukaemia.
Researchers hope to leverage the critical new insight to develop a blood test to monitor cancer patients with tissue damage, which could, in future, enhance treatment strategies for blood cancers and other diseases.
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Dietary Interventions Influencing Neurological Outcomes
With over a decade of experience as a dietitian and nutritionist, Carolina Blagojevic Castro specialises in providing personalised dietary guidance and customised meal planning tailored to meet each client’s unique health needs. She is known for her engaging and educational presentations on topics related to health and nutrition, sharing practical, evidence-based insights with both community groups and professional audiences.
