DEVELOPING THE NEXT GENERATION OF MEDICINES THAT TARGET AND ENHANCE THE MICROBIOME Groundwork laid for a future of cultured microbiome therapies targeting specific diseases
INTERVIEW
Associate Professor Sam Forster, CSL Centenary Fellow, Research Group Head
Microbiota and Systems Biology, Hudson Institute of Medical Research
& Team Leader, Australian Microbiome Culture Collection
& Chief Scientific Officer, BiomeBank
Dr Sam Costello,
Co-founder & CEO
BiomeBank
SEGMENT
Filmed in Melbourne and Adelaide | December 2024
Australian Health Journal spoke to Associate Professor Sam Forster, Research Group Head, Microbiota and Systems Biology, Hudson Institute of Medical Research, Team Leader, Australian Microbiome Culture Collection & Chief Scientific Officer, BiomeBank and Dr Sam Costello, Co-Founder and CEO of BiomeBank about the microbiome, partnering and some of the breakthroughs in recent years.
Assoc Prof Forster describes the role of the microbiome, “Every one of us carries thousands of bacteria. Millions of individual cells, and they’re intimately associated with all sorts of sites on our bodies. So our gut is the most common place we think about, but our lungs, our skin, everywhere. Where there’s an interface, the external environment, there’s bacteria and other microbes that actually enable us to interface with the external world. They detect changes and they regulate our immune response.”
This can be really important from a health perspective because they indicate when things are going well, we should have a healthy state or something’s gone wrong, and there is an inflammatory response. This can then be detrimental, or it can help clear a particular condition.
“The microbes we carry are intimately associated with our health.”, says Assoc Prof Forster. He was the founder of the Australian Microbiome Culture Collection at Hudson that now contains over 40,000 bacterial isolates. This provides a resource for further research.
“All of these opportunities are available because we have this vast collection of microbes where we can say this particular combination for you is relevant for this experiment. Taking clinical samples, we then can replicate the host environment using microfluidic organ on-a-chip systems”, says Assoc Prof Forster.
Microbiome therapies involve modifying the body’s microbial communities to improve health. These treatments aim to restore balance to the microbiome, potentially alleviating conditions like inflammatory bowel disease, liver disorders, autoimmune diseases, and certain cancers.
The Hudson Institute of Medical Research and BiomeBank have partnered to advance microbiome-based therapeutics. Their collaboration focuses on identifying key bacteria involved in disease onset and resolution, particularly associated with the gut. By combining their expertise, they aim to develop targeted microbial therapies to treat and prevent diseases by restoring gut microbial ecology.
BiomeBank develops and delivers microbiome therapies. In 2022 BiomeBank was successful in introducing the world’s first approved donor derived microbiome therapy approved in Australia for the treatment of C. Difficile infection.
Through this collaboration, the Hudson Institute and BiomeBank are at the forefront of microbiome research, striving to translate scientific discoveries into effective therapies that can improve patient outcomes.
As Dr Costello states, “We see microbiome therapies evolving in the next few years from predominantly donor derived therapies that are harvested from screened healthy stool donors, towards cultured therapies that can be grown in bioreactors and produced under controlled conditions.”
Assoc Prof Forster has been involved in a number of breakthroughs in culturing previously thought to be unculturable organisms.
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Rural allied health mentorship program creates opportunities for students and practice
Melanie Roll, a director and physiotherapist at Gen Health Hamilton, is dedicated to nurturing the next generation of allied health professionals. Gen Health’s support begins with a work experience program for local secondary school students, where they can observe a variety of health services and participate in an annual careers night to explore allied health career pathways.
Upon moving to tertiary education, students are offered placements through a five-week program designed to transition them from observation to supervised practice and ultimately to seeing their own patients. In their final study year, they can apply for the mentorship program, which aids the transition into private practice.
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Emerging researcher appointed to James Packer Chair in Mood Disorders at UNSW
The UNSW Discipline of Psychiatry and Mental Health is widely renowned as the pre-eminent psychiatry research department in the country and one of the leading university psychiatry research groups internationally. In 2023 it celebrated 60 Years of Psychiatry & Mental Health at UNSW Sydney.
Australian Health Journal spoke with Professor Kimberlie Dean, Head of the Discipline of Psychiatry and Mental Health at UNSW Sydney, about the recent appointment of mental health disorders expert and clinician researcher Dr Aswin Ratheesh to lead the James Packer Chair in Mood Disorders at UNSW Sydney. -
Global GP Conference comes to Australia
Over 3000 delegates from around the World will gather at the 50th celebration of WONCA to reconnect and revive General Practice, sharing knowledge and learnings on access, equity, funding, and multidisciplinary care teams. This includes networking with Australian and overseas GPs and in particular learning about primary care practices in other countries.
Australian Health Journal met with Dr Nicole Higgins, President of RACGP in transit at Brisbane Airport recently and she spoke about the $6 Billion allocated in the Federal Budget in May as a significant achievement for General Practice investment. She also emphasised this announcement reinforced GPs should be at the centre of multidisciplinary care teams to ensure continuity of care and better health outcomes.
