METABOLIC PHENOTYPING, LIPIDOMICS & BIOINFORMATICS IN DEMENTIA
With
Dr Luke Whiley
Curtin Medical Research Institute,
Western Australia
RESEARCHER PROFILE
Filmed in Perth, Western Australia | February 2026
Dr Luke Whiley is a dementia researcher whose work focuses on understanding how the body’s metabolism, particularly the biology of fats known as lipids, influences our health throughout ageing.
His research explores how the body responds to illness, lifestyle, and environmental stress at a chemical level, and how these responses shape longterm disease risk. Using advanced blood-based measurement technologies, Dr Whiley studies thousands of small molecules at once to build a snapshot of a person’s metabolic health. By combining these measurements with data science approaches, his work identifies biological pathways that become disrupted in disease, providing insight into why some people are more vulnerable to conditions such as dementia.
A major focus of Dr Whiley’s research is Alzheimer’s disease, where he investigates how genetic risk, particularly variations in genes involved in lipid transport, may affect metabolism across the body and lead to disease. This work highlights the importance of lipids in brain health, helping shift dementia research beyond proteins alone to include broader metabolic processes.
He also studies related questions in Parkinson’s disease, traumatic brain injury, and COVID19, where metabolic disruption plays a key role in recovery and longterm outcomes. Alongside discovery research, Dr Whiley develops methods that allow detailed metabolic testing using much smaller samples, making future screening and monitoring more accessible.
His overarching goal is to improve understanding, earlier detection, and prevention of neurodegenerative disease, while keeping people with lived experience at the centre of dementia research.
Source: Supplied
https://orcid.org/0000-0002-9088-4799
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Oral administration of insulin for Type 1 Diabetes
Huiwen Pang is a 3rd year PhD candidate in the Australian Institute for Bioengineering and Nanotechnology, University of Queensland, focusing on biomedical health research. Prior to commencing his PhD, Huiwen studied animal genetics in his Masters degree at Huazhong Agriculture University in China.
People with diabetes, especially Type 1 diabetes, largely rely on the insulin injections or insulin pumps to control their high blood glucose levels, which is painful and has a high risk of infections.
Huiwen Pang is conducting research on nano-based drug formulations for Type 1 diabetes treatment, with a focus on using nanomaterials to load insulin for oral administration and employing anti-apoptotic and anti-inflammatory approaches to mitigate damage to beta cells.
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Therapy to prevent hepatocellular carcinoma in people with liver cirrhosis
Professor John Olynyk is a Gastroenterologist & Hepatologist with over 30 years’ experience, primarily at The Fiona Stanley & Fremantle Hospital Group. He planned the Gastroenterology and Hepatology Service for the Fiona Stanley Hospital and was Head Department from 2010 until 2020.
Professor John Olynyk was appointed as Associate Dean and Head of the Medical Discipline at Curtin University in 2023 until 2025 and is now Associate Director, Clinical Engagement, Curtin Medical Research Institute, Curtin University.
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Patient reported outcomes in the diagnosis and treatment of lymphoma
Dr. Elizabeth Goodall (BMedSci Hons, MBBS Hons, FRACP, FRCPA) is a PhD student and early career researcher with La Trobe University and the Olivia Newton John Cancer Research Institute (ONJCRI), and Haematologist at Austin Health and Monash Health, Melbourne.
Her specific interest in how patients experience their illness and treatment forms the basis for her research in improving patient outcomes. This research comes at a pivotal time in modern lymphoma management with an ever-increasing number of treatment options available and renewed focus on each patient’s journey.
