HORMONE RECEPTOR POSITIVE BREAST CANCER AND THERAPY RESISTANCE
Professor Elgene Lim
Laboratory Head Connie Johnson Breast Cancer Research Lab,
Garvan Institute of Medical Research, Sydney &
Oncologist, The Kinghorn Cancer Centre, St Vincent’s Hospital, Sydney
RESEARCHER PROFILE (Filmed in Brisbane, Queensland, Australia | October 2024)
Prof Elgene Lim is a medical oncologist at St Vincent’s Hospital and Head of the Connie Johnson Breast Cancer Research Lab at the Garvan Institute. Following his PhD at the Walter & Eliza Hall Institute where he identified the aberrant cells in carriers of the BRCA1 mutant gene, a hereditary breast cancer syndrome as the culprit cells giving rise to breast cancer, he furthered his research and clinical training at the Dana-Farber Cancer Institute and Harvard Medical School. He was awarded the National Breast Cancer Foundation Practitioner Fellowship in 2014 and returned from Boston to Australia. In 2017, he was awarded the inaugural National Breast Cancer Foundation Endowed Chair, and subsequently appointed the Principal Cancer Theme Lead at UNSW.
His research focus is in the area of breast cancer, specifically bringing laboratory findings into clinical studies and evaluation of novel therapies in clinical trials. His team, in partnership with patients, have established a large panel of patient derived breast cancer avatars in mice, which allow for the study of breast cancer biology and the evaluation of novel therapies.
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De-prescribing medications in older adults with dementia
Dr. Daniel Hoyle is a Senior Lecturer in Therapeutics and Pharmacy Practice at the School of Pharmacy and Pharmacology, University of Tasmania. He is also an experienced clinical pharmacist with expertise in medication management in older people. Dr. Hoyle’s research interests focus on improving medicine use in older people with dementia.
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CASE STUDY High blood pressure and shorter sleep may worsen brain decline
People with high blood pressure who also lack sleep may be at increased risk of reduced cognitive performance and greater brain injury, Monash University research has found.
Published in the Journal of the American Heart Association, researchers assessed whether the combined effect of hypertension and short sleep duration had a negative impact on brain health.
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Interventions for improving outcomes of children who are deaf or hard of hearing
Dr Rithin Nedumannil (MBBS, MPH, FRACP, FRCPA) is a PhD candidate at the University of Melbourne, undertaking his doctoral studies in collaboration with the Cambridge Stem Cell Institute (Cambridge, UK) and the Peter MacCallum Cancer Centre (Melbourne, Australia). He is a clinical haematologist and haematopathologist with current appointments at Peter MacCallum Cancer Centre, the Royal Melbourne Hospital, Austin Health and Northern Health.
