FOOD AND FASTING PERIODS AS MEDICINE TO PREVENT DISEASE
Professor Leonie Heilbronn
University of Adelaide &
Group Leader Obesity and Metabolism,
South Australian Health and Medical Research Institute (SAHMRI)
Adelaide, South Australia
RESEARCHER PROFILE
Filmed in Adelaide, South Australia | February 2025
Professor Leonie Heilbronn is based at the South Australian Health and Medical Research Institute (SAHMRI), where she leads the Obesity and Metabolism laboratory. Her research is at the interface between basic and clinical science. She is internationally recognised for her work in nutritional modulation in humans and has made major contributions to our current understanding of mechanisms underlying conditions such as insulin resistance, particularly inflammation and lipid metabolism. She has also contributed significantly to current concepts of caloric restriction (CR), intermittent fasting (IF) and time restricted eating (TRE) in humans. She has published more than 110 peer reviewed papers in scientific journals and is an Associate Editor of Obesity, and Obesity Research and Clinical Practice.
Prof. Heilbronn is a translational investigator in obesity and diabetes research. She has a particular interest in understanding how fasting and meal timing alter nutrient signalling pathways to improve health and contributed extensively to current concepts in calorie restriction, intermittent fasting and time restricted eating. She has published more than 140 peer-reviewed manuscripts, and has a current h-index of 44. She is an Associate Editor of Obesity and the European Journal of Endocrinology. She is President of the Australia and New Zealand Obesity Society and an Associate Member of the Australian Academy of Health and Medical Science.
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Links investigated between poor sleep and onset of dementia
Watch Samantha Bramich, a PHD candidate at the Wicking Dementia Research and Education Centre, University of Tasmania talk on identify the prevalence of rapid eye movement sleep behaviour disorder (RBD) in Tasmania and how poor sleep contributes to the onset of dementia and other diseases.
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Genetic disease research imitating function and architecture of organs
Professor Wolvetang was among the first to bring the first human embryonic stem cells to Queensland, with his Wolvetang Group at the AIBN now renowned for its work with organoids: growing them, studying them, and using them to try and understand diseases and human development.
Using cutting edge technology, Professor Wolvetang designs and grows organoids both for their own work and for labs across the country, coaxing pluripotent stem cells or tissue samples into 3D structures that mimic the function and architecture of real brains, livers, kidneys, spinal cords, and intestines.
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CASE STUDY Link between levels of extracellular vesicles in the blood and tissue damage caused by diseases
A landmark study led by WEHI and La Trobe University has found a potential new diagnostic marker that could be used to better detect the level of tissue damage in our bodies.
This study revealed, for the first time, a link between levels of EVs in the blood and tissue damage caused by diseases such as leukaemia.
Researchers hope to leverage the critical new insight to develop a blood test to monitor cancer patients with tissue damage, which could, in future, enhance treatment strategies for blood cancers and other diseases.
