INNER EAR ORGANOIDS FOR THE STUDY OF HUMAN HEARING AND BALANCE
Dr Jackie Ogier
Passe & Williams Post-Doctoral Research Fellow
Audiology and Speech Pathology
University of Melbourne
RESEARCHER PROFILE (Filmed in Melbourne | August 2024)
Dr Jackie Ogier is an auditory neuroscientist, with a research focus on the molecular biology of hair cells, the specialised sensory receptors in the ear that detect sound and balance. She is a postdoctoral research fellow in the laboratory of A/Prof Bryony Nayagam, supported by a prestigious Passe and Williams foundation fellowship.
Dr Ogier completed her PhD in Neuroscience at the University of Melbourne in 2020, where she investigated the pathogenic mechanisms underlying hearing loss and identified a novel molecular target for preventing aminoglycoside-induced hearing damage. She performed this research at the Murdoch Children’s Research Institute under the guidance of A/Prof Paul Lockhart, A/Prof Bryony Nayagam, and Dr Rachel Burt. During this time, she was President of the Research Students Association and a member of the MCRI Honours and Children’s Campus Graduate Research Training Committees. For her service to discipline, she was recognised with the MCRI Rising Star award in 2017.
Dr Ogier then undertook post-doctoral training at the Sunnybrook Research Institute (University of Toronto) with Prof Alain Dabdoub, where she optimised the collection, dissection, and culture of donated human cochleae for single cell sequencing. She also received The University of Toronto’s Dr Ian Witterick Research Prize in Otolaryngology Head & Neck Surgery for her continued ototoxicity research. Jackie subsequently established a collaboration between the Universities of Toronto and Melbourne to develop an “inner ear in a dish” that will accelerate hearing and balance discovery research.
Dr Ogier’s experience broadly spans the genetics of hearing loss, disease modelling, micro dissection, primary cell culture, stem cell culture, organoids, and proteomics. Overall, she aims to generate knowledge of hearing and vestibular sensory biology.
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CASE STUDY Large scale genetic study finds link between Irritable Bowel Syndrome & cardiovascular system
Research published April 2024 in the journal Cellular and Molecular Gastroenterology and Hepatology sheds light on disease mechanisms common to irritable bowel syndrome (IBS) and cardiovascular diseases (CVD).
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Earlier identification and early intervention for children who are deaf or hard of hearing
Professor Greg Leigh A held a variety of positions in the education of children who are deaf or hard of hearing before entering academia. He holds a degree in Special Education from Griffith University, a Master of Science (Speech and Hearing) from Washington University and a PhD in Special Education from Monash University. In 2001, he was made a Fellow of the Australian College of Educators and in 2014, he was invested as an Officer in the Order of Australia (AO) for distinguished services to the deaf and hard of hearing community.
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Novel therapy for pancreatic cancers, targeting molecular foundation
Dr Michael Lee is an experienced medical oncologist, sub-specialising in gastrointestinal cancers and neuroendocrine tumours at the Peter MacCallum Cancer Centre.
He plays a key role in molecular tumour boards at VCCC Alliance (Victorian Comprehensive Cancer Centre) and MPCCC (Monash Partners Comprehensive Cancer Consortium), ensuring the accurate and effective use of precision medicine in cancer care across the state.
